Dysregulation

The hypothalamus (the part of the brain that works directly with the pituitary gland to produce hormones) is also a "target" for 'post-infectious immune-mediated' disease. As such, GBS can impact the hypothalamus which regulates homeostasis via functions of hypocretin affecting regulatory areas for thirst, hunger, body temperature, water balance, blood pressure, and especially sleep and arousal states with links from the nervous system to the endocrine system.

hypothalamic involvement in GBS via damage to neurons in the hypothalamus

There is strong evidence that narcolepsy is associated with abnormalities of the hypocretin neurotransmitter system.